Previous in vitro and in vivo studies have shown that Maresin 1 improves insulin sensitivity in diet-induced obese mice (17), delays the progression of non-alcoholic fatty liver disease (18), plays a protective role in a mouse model of colitis (31), and ameliorates Treg/Th17 imbalance in rheumatoid arthritis (32). Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.