EDN1 and sarcopenia: Skeletal muscle has plasticity of regeneration and remodeling due to MuSCs function, and the age-related decline of skeletal muscle mass and function (known as sarcopenia) is associated with loss of MuSCs regenerative capacity with aging (Sousa-Victor and Munoz-Canoves, 2016).Researches about some factors such as endothelin-1, TRIM32, and GSK-3α inducing MuSCs senescence, in which knockout of each of these factors results in muscle degeneration and sarcopenia development, have been carried out in this field (Kudryashova et al., 2012; Zhou et al., 2013; Alcalde-Estévez et al., 2020).