Grassian et al. (2012) reported a direct correlation between intracellular 2-HG levels and EMT characteristics. Citrate synthase (CS) is another TCA cycle enzyme that is associated with EMT. CS knockdown induced morphological changes consistent with EMT features in cervical cancer and resulted in enhanced metastasis and proliferation in in vitro and in vivo models. (Lin et al., 2012). Here, CS is linked to cervical cancer.