PDP1 and cancer: Consistent with EMT-like changes, inhibition of PDH increased resistance of cancer cells to all of the drugs tested in this study, while cell viability was drastically reduced in non-treated cells upon treatment with the cytotoxic agents (cisplatin, doxorubicin, etoposide, 5-FU, and gemcitabine) (Figure 5; Supplementary Figure S12).