CD4 and gastric cancer: Additionally, the distribution of the activity score of “T-cell activation” was decreased in CD8+ T cells from the high-risk group (Figure 4I) and the activity score of “T cell antigen and presentation” was also exhibiting the decreased tendency in CD4+ T cells from the high-risk group compared with the low-risk group (Figure 4J), which indicated the poor prognosis in high-risk GC patients might be associated with the dysregulation of T cell-function.