We propose conducting studies that monitor Latinx persons with prediabetes and their lifetime and prospective exposure to structural, institutional and interpersonal racism in relationship to their physiological stress responses (in both the HPAA and ANS systems), biological mediators of inflammation (e.g., IL-6, CRP, TNF-α), and their surrogate (insulin) and clinical endpoints (HbA1c, fasting plasma glucose) (see Figure 2). This evidence concerns the gene INS and prediabetes syndrome.