PMEL and neoplasm: Meanwhile, due to the existence of melanoma major antigens such as gp100 and tyrosinase-related protein (TRP)-2 on the surface of CpG-CCNPs, it can strongly generate gp100-specific and TRP-2-specific T cells in the spleen, verifying the previous speculation that the nanoparticles were able to train the immune system against various tumor antigens.