The first one demonstrated an OS improvement compared to standard chemotherapy (HR = 0.64 [95% confidence interval, 0.43–0.96], P = 0.03) without significant OS benefit between ICPIs and chemotherapy in KRAS wt NSCLC (HR = 0.88 [95% confidence interval, 0.68–1.13], P = 0.30) (41). This evidence concerns the gene KRAS and non-small cell lung carcinoma.