VEGFA and neoplasm: It was also reported that metronomic chemotherapy, which was defined as using small doses of the high-frequency chemotherapeutic drug to achieve a lower but effective range of drug concentrations over long periods without significant toxicity, could downregulate VEGF, further upregulating the expression of TSP-1 to play an important role in inhibiting tumour angiogenic dormancy (45–47)[a-c].