To investigate whether PIWIL1 mediated chemoresistance in MM, we exposed a panel of transfected RPMI-8226 MM and NCL-H929 cells to the indicated concentrations of bortezomib (5 nM and 10 nM, respectively), dexamethasone (80 μM and 100 μM, respectively), or doxorubicin (20 nM and 25 nM, respectively). This evidence concerns the gene PIWIL1 and Miyoshi myopathy.