To determine the mechanism of inhibitory effects of DPSC-CM on CRC cells, the expression of apoptotic proteins (pro and cleaved-caspase 3, pro and cleaved-caspase 8, cytochrome C, ERK (P44/42), p-ERK (P44/42), JNK/SAPK, p-JNK/SAPK, and β-Catenin) were compared in the Caco2, SW48 and HUVEC cells treated with DPSC-CM or FBS free medium. This evidence concerns the gene CASP8 and colorectal carcinoma.