Cytochrome C, phospho-JNK/SAPK to JNK/SAPK ratio, cleaved-caspase 8 and 3 were all increased in treated CRC cells with DPSC-CM, and phospho-ERK (P44/42 MAPK) to ERK (P44/42 MAPK) ratio was decreased while minimal change was seen in normal cells. Here, MAPK8 is linked to colorectal carcinoma.