In the current study, we discovered that a stressful situation was the outcome in a higher MPO content and a marked increase in the inflammatory neutrophil count compared with the normal group, while rats treated with the CB1R agonist NADA and CB2R antagonist AM630 had significantly reduced TNF- α, IL-1 β, and MPO compared with the stress ulcers group. Here, CNR1 is linked to duodenal ulcer.