In various cancers, our enrichment analysis revealed that COL5A1 potentially influences the etiology or pathogenesis of cancer through immune-related pathways, chemokine pathways, negative regulation of immune system processes, JAK-STAT pathways, T cell receptor pathways, lymphocyte migration, NOD-like receptor pathways, antigen processing and presentation, MAPK pathways, and adaptive immune responses based on the somatic recombination of immune receptors built from immunoglobulin superfamily domains. This evidence concerns the gene COL5A1 and cancer.