The results illustrated that COL5A1 was upregulated in 13 cancers, including breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOL), COAD, esophageal carcinoma (ESCA), GBM, HNSC, kidney renal clear cell carcinoma (KIRC), LIHC, lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), rectal adenocarcinoma (READ), STAD, and thyroid carcinoma (THCA). The gene discussed is COL5A1; the disease is thyroid gland carcinoma.