In fact, low-density lipoprotein receptor-related protein 6 (LRP6) is one of the members of the low-density lipoprotein receptor (LDLR) family and significantly regulates lipid metabolism via several Wnt/β-catenin signaling pathways and is critically involved in various cardiovascular diseases including coronary artery disease [6]. This evidence concerns the gene LDLR and coronary artery disorder.