Moreover, it upregulated the expression of brown fat markers including PR domain containing 16 (PRDM16), uncoupling protein 1 (UCP1), and PPARγ coactivator-1 (PGC-1α), which reduced obesity and restored metabolic homeostasis by altering brown fat phenotype [212]. Here, PRDM16 is linked to obesity due to melanocortin 4 receptor deficiency.