Demethoxycurcumin with an LD50 value of 4000 is categorized as class V, toxic, and is predicted to elicit an immunotoxicity and active interaction with mitochondrial membrane protein (MMP) and a bit less probable interaction with heat shock response element (HSE) and nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf/ARE). The gene discussed is NKRF; the disease is immune system toxicity.