NFE2L2 and immune system toxicity: The dihydrocurcumin is identified for LD5O value of 2000 mg/kg and thus is catergorized as class IV toxic substance, is assumed to trigger significant off-target interactions, including one that might result in immunotoxicity, actively interacts with peroxisome proliferator-activated receptor gamma (PPAR-gamma), nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE), heat shock factor response element (HSE), and mitochondrial membrane potential (MMP), and may interact with phosphoprotein (tumour suppressor) p53.