Cancer cells overexpressing MOAP-1 exhibit enhanced sensitivity, while cancer cells overexpressing BCL-XL are resistant to α-mangostin-mediated apoptosis, suggesting that α-mangostin induces apoptosis through mitochondria signaling pathway involving the activation of both MOAP-1 and act-BAX while downregulating the expression of BCL-XL. Here, MOAP1 is linked to cancer.