Studies have shown that miR-194 inhibits the expression of PTBP1 by binding to the 3′-UTR of PTBP1 mRNA, and induces the reduction of CCND3 levels and the growth of liver cancer cells; in addition, the alignment with the miR-194/PTBP1/CCND3 axis can be used as a new strategy for the treatment of human HCC is used (Kang et al., 2019). This evidence concerns the gene PTBP1 and hepatocellular carcinoma.