NK cells isolated from NSCLC tissues exhibited an inhibited phenotype, with decreased activating receptors NKp30, NKp80, CD16, NKG2D, ILT2, and DNAM-1 and increased NKp44, NKG2A, CD69; these cells were also functionally impaired compared to circulating peripheral blood NK cells based on decreased tumor killing and degranulation in tumor cell co-culture (147). The gene discussed is CD226; the disease is neoplasm.