Likewise, intra-tumoral NK cells from invasive breast cancer expressed less NKp30, NKG2D, DNAM-1, CD16, CD25, CD57, perforin, granzyme, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as well as higher NKG2A and NKp44 compared to both normal breast tissue and carcinoma in situ (20). This evidence concerns the gene KLRC1 and invasive breast carcinoma.