In conclusion, this study reinforces the involvement of several immune cell subtypes and genes in fibrosis-related immune response pathways, including the IL-17, IL-4 and IL-13 signaling pathways, as well as ECM organization and degradation processes, providing key evidence for epigenetic keloid genes, deepening our understanding of changes in the keloid fibroblast process, and revealing the key candidate genes affecting keloid formation. Here, IL4 is linked to keloid.