The high expression levels of RAB7A, PIK3C3, ATP6AP1, ATP6V1A, CCDC22, and NPC1 were significantly associated with lower tumor purity of patients with hematologic cancer LAML, while TMPRSS2, PIK3C3, ATP6AP1, and ATP6V1A expressions were obviously correlated with higher tumor purity of KICH patients. The gene discussed is CCDC22; the disease is neoplasm.