These findings indicate that LUSC and LUAD patients may have a varying degree of adverse outcomes if they are infected with SARS-CoV-2 because of the opposite interaction between OAS1 and TMPRSS2 in LUAD and LUSC as well as the opposite effect of these lung cancer-related genes on the prognosis of LUAD and LUSC. Here, TMPRSS2 is linked to lung carcinoma.