Taking together, these findings indicate that BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, and THCA patients carrying rs10774671-A (OAS1) genotype may be more likely to have poor COVID-19 outcomes relative to those carrying rs10774671-G because individuals carrying rs10774671-A will have the lower expression of OAS1, which serves as a protective factor against SARS-CoV-2 progress and poor COVID-19 progress outcomes. This evidence concerns the gene OAS1 and COVID-19.