Given that ACE2 and NPC1 were significantly upregulated in the normal tissues and cells or tumor cells of the respiratory system infected after SARS-CoV-2, these findings indicate that LUSC or LUAD patients infected with SARS-CoV-2 may have a worse outcome because SARS-CoV-2-induced ACE2 and NPC1 elevation may have a negative influence in C3 and a positive effect on the C1, C2, and C6 immune infiltration of LUSC, or have a negative influence in CD8+T of LUAD. This evidence concerns the gene CD8A and neoplasm.