Interestingly, bronchial epithelial cells from patients with mild and severe asthma display impaired mRNA expression of HLA-G1, -G4, and -G5 functional isoforms and HLA-G expression is not affected by IL-13 supporting the hypothesis that an impaired expression of HLA-G isoforms in asthmatic patients could contribute to the loss of inflammation control and epithelium structural remodeling (64). The gene discussed is HLA-G; the disease is asthma.