Additionally, in our cohort of patients at metabolic risk, we found that TRL particles and NMR-glycoproteins had a positive association with hepatic dysfunction markers, including the fatty liver index (FLI) and ALT, AST and GGT, serum markers that have been used extensively to generate multiple scores and indexes for the non-invasive assessment of fatty liver disease (26, 27, 36–40). The gene discussed is GPT; the disease is fatty liver disease.