It is interesting to note that comparing asymptomatic patients with carotid plaque and non-carotid plaque, the correlation analysis showed that the ALPS-index was not a significant sign correlated with sex, age, MBP, FBS, TG, LDL-c, cognitive function score (MMSE), pulse pressure, history of hypertension, diabetes, and hypercholesterolemia. The gene discussed is MBP; the disease is familial hypercholesterolemia.