SCARB1 and atherosclerosis: However, in apoCIII-transgenic hypertriglyceridemic mice or SR-BI knockout mice, CETP expression limits atherosclerosis progression, suggesting CETP overexpression could be atheroprotective in the presence of hypertriglyceridemia (Hayek et al., 1995; Forrester et al., 2005; Harder et al., 2007).