Raposo et al. (2021) recently demonstrated that CETP expression attenuates adiposity in both huCETP and sCETP transgenic mice by enhancing lipolysis and energy expenditure. In clinic, blood CETP mass and activity are increased with obesity in non-diabetic humans (Arai et al., 1994; Magkos et al., 2009) and the reduced expression of CETP is associated with the development of type II diabetes in obese subjects (Kahri et al., 1994; MacLean et al., 2000, 2005). This evidence concerns the gene CETP and obesity due to melanocortin 4 receptor deficiency.