EDN1 and congestive heart failure: Moreover, higenamine decreases serum level of neuro-humoral factor, such as renin, angiotension II (Ang-II), aldosterone (ALD), and endothelin-1 (ET-1); serum level of myocardial biomarkers, such as brain natriuretic peptide (BNP), NT-proBNP, lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and aspartate aminotransferase (AST); but increases the serum level of adenosine phosphate, such as adenosine triphosphate (ATP), ATPase, nicotinamide adenine dinucleotide (NAD), and NADH in CHF rats induced by DOX (Wen et al., 2020b; Wen et al., 2020c).