AKT1 and hereditary clear cell renal cell carcinoma: Based on these findings, it could be speculated that besides PI3K/Akt/mTOR pathway, TAK1-dependent inactivation of JNK/AP-1, and IKK signaling may be also responsible for the inhibitory effects of NVP-BEZ235 and PP242 against renal cell carcinoma but not Rapamycin.