Additionally, it can activate anti-apoptotic pathways, such as phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signal cascade (Bourguignon et al., 2007) and B lymphocyte tumor-2 gene (Bcl-2) and Bcl-xl transcription to enhance the survival ability of tumor cells (Madjd et al., 2009). The gene discussed is AKT1; the disease is neoplasm.