• Parthenolide: It can achieve anti-tumor effect by inhibiting B-Raf/MAPK/Erk signaling pathway, inhibiting NF-κB activation, and inhibiting PI3K/AKT signaling pathway (Jeyamohan et al., 2016; Kim et al., 2017; Lin et al., 2017). This evidence concerns the gene AKT1 and neoplasm.