In addition, other emerging targets such as o-GlcNAcase (Paul et al., 2019; Wang et al., 2020) and GSK-3β (Liang et al., 2016; Hu et al., 2017; Prabhakaran et al., 2017; Bernard-Gauthier et al., 2019; Varlow et al., 2021) that associated with tauopathy remain to be explored in tauopathy models. The gene discussed is OGA; the disease is tauopathy.