Recent advances in molecular imaging using PET and MRI have provided valuable insights into the time course of disease pathophysiology in tau animal models, including tau, neuroinflammation, and structural and functional alterations (Ishikawa et al., 2018; Ni et al., 2018; Tagai et al., 2020), thus providing a blueprint for tauopathy disease clinical study. Here, MAPT is linked to tauopathy.