GLI1 and Peripheral demyelination: On the other hand, the pathway regulates NPC proliferation in the SVZ from healthy adult mice (Ferent et al., 2014; Daynac et al., 2016), whereas blockade of Gli1 is necessary to recruit a subset of NPCs that exclusively differentiate into oligodendroglial cells in mouse models of CNS demyelination (Samanta et al., 2015; Radecki et al., 2020).