In a comprehensive review of the role of the β-adrenergic system on ocular neovascularization, Casini et al. (2014) concluded that “in different experimental models, a decrease of the β-adrenergic function may result either in reduction or in exacerbation of the vascular changes, thus suggesting possible dual effects of β-AR modulation depending on the experimental setting.” Because the laser-induced CNV model is the gold standard for testing new treatments for wet AMD (Pennesi et al., 2012), future studies should focus on this model. Here, ADRB2 is linked to wet macular degeneration.