MM cell lines with (MM1S and H929) and without (U266, OPM2) RAS mutations were treated with Erk1/2i (0–16 μM for 24 h, 48 h, 72 h, 96 h) in the presence or absence of MM BMSC-conditioned media (BMSC-CM) (Fig. S1E). This evidence concerns the gene MAPK3 and Miyoshi myopathy.