Importantly, 30–50% drug-induced MM cytotoxicity was observed after 3D treatment with Erk1/2i + CDK4/6i in the presence/absence of autologous MM BMSC-CMs, indicating that this combination may overcome the protective effect of the MM-BM-milieu (Fig. 7A). The gene discussed is MAPK3; the disease is Miyoshi myopathy.