Larger et al. found a significant up-regulation of FBXO32 in ALS skeletal muscles that correlate with a decreasing AKT. Although they saw no difference in FoxO1 and FoxO3 levels between patient and control groups, the results of the study implied that inhibition of AKT induces FoxO activity by decreasing cytosol sequestration55. Here, FBXO32 is linked to amyotrophic lateral sclerosis.