A KEGG pathway analysis also revealed 69 other pathways overrepresented in the putative targets of hsa-let-7f-5p and hsa-miR-451a, including “MAPK signaling pathway”, “PI3K-Akt signaling pathway”, “Amyotrophic lateral sclerosis” and “apoptosis”33. This evidence concerns the gene AKT1 and amyotrophic lateral sclerosis.