Analysis of bulk RNA-Seq revealed a decrease in WSCD2 gene expression in the samples from TCGA breast cancer patients with the genotype homozygous for the minor alleles (Fig. 2d,e) and core gene networks of transcription factors, growth factors and insulin indirectly associated with MT-ND4 (Fig. 2g,h). The gene discussed is MT-ND4; the disease is breast cancer.