Herein, we explored the TP53 full-gene genomic status in a cohort of newly diagnosed MM patients and in a subgroup for whom longitudinally collected samples were available, in order to determine, by means of single-nucleotide polymorphisms (SNPs) array and targeted sequencing, the prognostic significance of TP53 CN and mutational events, as well as their evolution along the disease course. The gene discussed is TP53; the disease is Miyoshi myopathy.