PCSK9 and triple-A syndrome: We have previously demonstrated that the conditional deletion of Netrin-1 in monocyte and macrophages Ntn1flox/floxLysMcre+/− (NKO) protected mice from developing AAA compared to Ntn1flox/flox mice (WT) when challenged to AAA via Proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9) overexpression combined with Western diet and Ang II infusion23 (Fig. 5a).