This provides additional mechanistic evidence that targeting the MEK/ERK pathway may enhance the efficacy of ruxolitinib by antagonizing inflammatory cytokine expression, as shown by Stivala et al. [65] who used MPN mouse models to show that combining MEK and JAK2 inhibition provides greater suppression of ERK target genes and cytokine expression. This evidence concerns the gene MAP2K7 and myeloproliferative neoplasm.