Interestingly, using single cell RNA-seq Psaila et al. [80] identified YBX1 expression among several genes identified as potential regulators of differentiation of hematopoietic stem cells toward the megakaryocyte lineage, as compared to erythroid differentiation, in myelofibrosis patients and not healthy individuals. The gene discussed is YBX1; the disease is myelofibrosis.