Cytogenetic and global transcriptomic analyses led to the classification of T-ALL into molecular subgroups characterized by the abnormal expression of specific transcription factors (TF) (TAL1; LMO1/2; TLX1/3; LYL1; HOXA; MEF2C) and their blocked differentiation at specific stages of maturation [1, 7, 8]. This evidence concerns the gene TF and acute lymphoblastic leukemia.