Such markers include interleukin-18 (IL-18) and interleukin-1 receptor antagonist (IL-1Ra) implicated in among others rheumatoid arthritis (RA), a proliferating-inducing ligand (APRIL) involved in RA and systemic lupus erythematosus (SLE), interleukin-6 (IL-6) in RA and inflammatory bowel disease (IBD) and soluble interleukin-2 receptor (sIL-2R) as a marker of T-cell activation involved in a wide range of autoimmune disorders like IBD and SLE [19–22]. This evidence concerns the gene IL6 and rheumatoid arthritis.