SC-Caller [66] identified 598 SNVs distributed over the genome portion not affected by CNVs, including several variants detected in the original study (e.g., LINGO2, IL7R, MYH11, FUS, PTPRD, LRP1B, TSHZ3), as well as other mutations affecting essential driver genes in CRC (e.g., APC, TP53, NRAS). This evidence concerns the gene LINGO2 and colorectal carcinoma.