Isoform variants, subunits or cleavage products of eight proteins that discriminated AD from control, according to the inclusion criteria, were identified: zinc α 2-glycoprotein (ZAG), histidine-rich glycoprotein (HRG) fragment, haptoglobin (Hpt), vitamin D binding protein (VDBP), complement factor I (CFI), inter-α trypsin inhibitor (ITHI), α-1 anti-trypsin (α1AT) and apolipoprotein E (ApoE). This evidence concerns the gene HRG and Alzheimer disease.