Targeting stromal PKN2 in a genetic metastatic PDAC model would provide an alternative albeit complex multi-locus model; targeting PKN2 through Cre-Lox recombination would necessitate pancreatic tumor induction through a non-Cre-driven model, such as the KPF mouse (Schonhuber et al., 2014). Here, PKN2 is linked to pancreatic neoplasm.