One thousand TB32048 (C57BL/6 background) cells were implanted into the pancreas to initiate syngeneic orthotopic tumor growth in both male and female littermate RosaCreERT+/WT: PKN2+/+ (WT), PKN2fl/+ (heterozygous [HET]), and PKN2fl/fl (KO) mice (C57BL/6 background). Here, PKN2 is linked to neoplasm.