STAT3 and neoplasm: This revealed almost identical phenotypic patterns across a broad set of tumor phenotypes; stromal PKN2 loss (orthotopics) or a high PKN2KO matrisome score (TCGA) is associated with high tumor EMT, inflammation, and IL-6-Jak-STAT3 and KRAS signaling, alongside a reduction in Myc targets, DNA repair, and oxidative phosphorylation (Figure 6G).