To comprehensively assess the effects of stromal PKN2 deletion on ECM components, and more globally on tumor biology, we conducted bulk RNA-sequencing (RNA-seq) analysis of all female PKN2 WT and KO tumors and conducted gene set enrichment analysis (GSEA); we prioritized the female tumors as we had samples for n ≥ 5 for WT and KO tumors, and the TB32048 cell line was derived from a female syngeneic mouse. The gene discussed is PKN2; the disease is neoplasm.