RHO and pancreatic neoplasm: As the Rho-YAP axis is implicated in CAF function (Calvo et al., 2013; Dupont et al., 2011; Wada et al., 2011; Zhao et al., 2012), we next sought to examine whether PKN2 loss could impact the reciprocal interaction between PSCs and pancreatic cancer (PDAC) cells.