As the Rho-YAP axis is implicated in CAF function (Calvo et al., 2013; Dupont et al., 2011; Wada et al., 2011; Zhao et al., 2012), we next sought to examine whether PKN2 loss could impact the reciprocal interaction between PSCs and pancreatic cancer (PDAC) cells. Here, YAP1 is linked to familial pancreatic carcinoma.