The EGFR‐positive and ALK&ROS1‐positive were more common in female (χ2 = 61.934, P < 0.001 and χ2 = 28.152, P < 0.001), non‐smoking (χ2 = 59.315, P < 0.001 and χ2 = 11.080, P = 0.001), and adenocarcinoma (χ2 = 44.864, P < 0.001 and χ2 = 12.318, P = 0.002) patients; proportion of patients with emphysema was lower (χ2 = 35.494, P < 0.001 and χ2 = 15.770, P < 0.001) than the wild‐type patients. This evidence concerns the gene EGFR and pulmonary emphysema.