As alpha-2 agonists interfere with the autonomic system andcognition (propofol, etc.), problems arise: a) how to switch from conventionalsedation to alpha-2 agonists (“switching”), e.g., in agitated or unstable patients,refractory delirium tremens (DT), circulatory/ventilatory distress,etc.; and b) how can alpha-2 agonists be prescribed as first-line sedatives de novoupon admission? This evidence concerns the gene PSMA2 and alcohol withdrawal delirium.