NPC1 and infection: In addition, inhibition of NPC1 function by the chemical compound U18666A, was also shown to inhibit the infection of Chikungunya, an alphavirus and, several flaviviruses such as Zika Virus (ZIKV), West Nile Virus (WNV), Yellow Fever Virus (YFV) and Dengue Virus (DENV) [25,29,31].