We hypothesized that the obesity induction time was not sufficient to surpass systemic homeostasis; therefore, excess cholesterol was taken up by the liver through LDL receptors mediated by the SCAP-SREBP pathway [63], which caused an increase in hepatic cholesterol, while serum levels remained the same compared to the control rats. Here, LDLR is linked to obesity due to melanocortin 4 receptor deficiency.