The induction of HCC with DEN/2-AAF resulted in a dramatic change in the functional activity of the liver represented by a significant (P<0.05) increase in the serum activities of ALT, AST, and ALP that was accompanied by a significant decrease in the serum concentrations of total protein and albumin when compared to normal rats as displayed in (Table 1(. Treatment with 1,8 cineole (100 mg/kg) and ellagic acid (60 mg/kg) for four weeks showed a significant (P<0.05) decrease in the serum activities of ALT, AST, and ALP compared with HCC untreated group. This evidence concerns the gene ALB and hepatocellular carcinoma.