KLF3 and neoplasm: There were no statistically significant differences in KLF3 mutation frequency according to tumor grade; mutations were present in 14.2% of grade 1 (4 of 28), 8.1% of grade 2 (3 of 37), and 13.2% of grade 3 (11 of 83) MSI tumors (Table J in S1 Table).