In appendicitis, where the infection can take the form of a ‘biofilm’ that is not directly accessible to the immune cells [3], there was marked increases in mRNAs coding for IL8 receptor-ß (IL8RB/CXCR2), and secondary granule proteins such as alkaline phosphatase (ALPL) [2]. This evidence concerns the gene CXCR2 and appendicitis.