Among the most shared cyt-HERVs, 11 were overexpressed in more than 10 different types of cancers, including 3 HERVs (herv_2256, herv_6069, and herv_4700) formerly reported to induce CD8+ T cell responses (10, 14, 15) (Fig. 1E). The gene discussed is CD8A; the disease is cancer.