Conversely, tumour‐suppressor functions of HOXB13 in prostate cancer seem to depend on its ability to block cell division through the downregulation of cyclin D1 through competition for TCF4 binding to its promoter,87, 88 and androgen signalling through direct interaction with the androgen receptor.89, 122. The gene discussed is HOXB13; the disease is prostate carcinoma.