Of these, the canonical wnt/β‐catenin pathway is the most common target of HOX regulation, being upregulated in lung cancer (HOXB5134, 138 and HOXB9130, 132), colorectal cancer (HOXB8),51 breast cancer (HOXD3),140 gastric cancer (HOXA13158 and HOXB5129), pancreatic cancer (HOXB5),159 osteosarcoma (HOXB8)49 and HNSCC (HOXB5).131. The gene discussed is HOXB8; the disease is breast cancer.