Other functional groupings of genes regulated by HOX proteins in cancer involve regulators of apoptosis, and in particular, caspase 3 that is repressed by HOXC13 in oesophageal cancer125 and HOXC10 in osteosarcoma,71 Bax that is upregulated by HOXC10 in osteosarcoma71 and the anti‐apoptotic gene BCL2 that is upregulated by HOXA10 in gastric cancer,156 HOXC10 in osteosarcoma71 and HOXC6 in HNSCC.157. The gene discussed is HOXC6; the disease is osteosarcoma.